Philadelphia Eagles at Cleveland Browns (-3)
- Point Spread: Browns favored by 3 points
- Over/Under: 47.5 points
Atlanta Falcons at New Orleans Saints (-3.5)
- Point Spread: Saints favored by 3.5 points
- Over/Under: 49.5 points
Detroit Lions (-2.5) at Carolina Panthers
- Point Spread: Lions favored by 2.5 points
- Over/Under: TBD
New England Patriots (-1.5) at Houston Texans
- Point Spread: Patriots favored by 1.5 points
- Over/Under: 48.5
Pittsburgh Steelers (-10) at Jacksonville Jaguars
- Point Spread: Steelers favored by 10 points
- Over/Under: 46.5 points
Cincinnati Bengals at Washington Football Team (-1.5)
- Point Spread: Washington favored by 1.5 points
- Over/Under: 46.5 points
Tennessee Titans at Baltimore Ravens (-5)
- Point Spread: Ravens favored by 5 points
- Over/Under: 48.5 points
Miami Dolphins (-3.5) at Denver Broncos
- Point Spread: Dolphins favored by 3.5 points
- Over/Under: 45.5 points
New York Jets at Los Angeles Chargers (-10)
- Point Spread: Chargers favored by 10 points
- Over/Under: 45.5 points
Green Bay Packers at Indianapolis Colts (-2)
- Point Spread: Colts favored by 2 points
- Over/Under: 51.5 points
Dallas Cowboys at Minnesota Vikings (-7)
- Point Spread: Vikings favored by 7 points
- Over/Under: 47.5 points
Kansas City Chiefs (-10) at Las Vegas Raiders
- Point Spread: Chiefs favored by 10 points
- Over/Under: 56.5 points
Los Angeles Rams at Tampa Bay Buccaneers (-4)
- Point Spread: Buccaneers favored by 4 points
- Over/Under: 48.5 points
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