Las Vegas Raiders (6-4) at Atlanta Falcons (3-7)
- Point Spread: Falcons favored by 3 points
- Over/Under: 53.5 points
Arizona Cardinals (6-4) at New England Patriots (4-6)
- Point Spread: Cardinals favored by 1.5 points
- Over/Under: 49.5 points
New York Giants (3-7) at Cincinnati Bengals (2-7-1)
- Point Spread: Giants favored by 6 points
- Over/Under: 44.5 points
Cleveland Browns (7-3) at Jacksonville Jaguars (1-9)
- Point Spread: Browns favored by 6.5 points
- Over/Under: 49.5 points
Carolina Panthers (4-7) at Minnesota Vikings (4-6)
- Point Spread: Vikings favored by 3.5 points
- Over/Under: 51.5 points
Tennessee Titans (7-3) at Indianapolis Colts (7-3)
- Point Spread: Colts favored by 3 points
- Over/Under: 51.5 points
Los Angeles Chargers (3-7) at Buffalo Bills (7-3)
- Point Spread: Bills favored by 5 points
- Over/Under: 52.5 points
Miami Dolphins (6-4) at New York Jets (0-10)
- Point Spread: Dolphins favored by 7 points
- Over/Under: 44.5 points
New Orleans Saints (8-2) at Denver Broncos (4-6)
- Point Spread: Saints favored by 6 points
- Over/Under: 43.5 points
San Francisco 49ers (4-6) at Los Angeles Rams (7-3)
- Point Spread: Rams favored by 6.5 points
- Over/Under: 44.5 points
Kansas City Chiefs (9-1) at Tampa Bay Buccaneers (7-4)
- Point Spread: Chiefs favored by 3 points
- Over/Under: 55.5 points
Chicago Bears (5-5) at Green Bay Packers(7-3)
- Point Spread: Packers favored by 8.5 points
- Over/Under: 45.5 points
Seattle Seahawks (7-3) at Philadelphia Eagles (3-6-1)
- Point Spread: Seahawks favored by 5 points
- Over/Under: 49.5 points
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